Management Change/Compensation (Form 8-K)

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On April 21, 2026, Andrew Gottesdiener, M.D. and Peter Harwin each notified the Board of Directors (the "Board") of Apogee Therapeutics, Inc. (the "Company") of his intention to resign from the Board effective May 11, 2026. The resignations of Dr. Gottesdiener and Mr. Harwin are not the result of any disagreement with the Company on any matter relating to the Company's operations, policies or practices. The size of the Board will be reduced from nine directors to seven directors effective May 11, 2026.