Material Agreement (Form 8-K)

On December 31, 2025, MeiraGTx Holdings plc (the "Company") entered into a share purchase agreement (the "Share Purchase Agreement")with Perceptive Life Sciences Master Fund, Ltd.("Perceptive Master Fund"), an affiliate of Perceptive Advisors LLC ("Perceptive Advisors"), pursuant to which the Company agreed to purchase 2,300,000 of the Company's ordinary shares, $0.00003881 par value per share (the "Ordinary Shares"), from Perceptive Master Fund at a price of $7.91 per share (which was the volume-weighted average price (VWAP) per share on the Nasdaq Global Select Market on December 31, 2025), for an aggregate purchase price of $18,193,000 (the "Share Repurchase"). Perceptive Master Fund elected to sell the shares in connection with year-end portfolio tax optimization activities.

Under the Share Purchase Agreement, Perceptive Master Fund agreed that it and its affiliates will not sell, transfer or dispose of any Ordinary Shares (the "Lock-Up Securities"), or any securities convertible into or exercisable or exchangeable for the Ordinary Shares,or otherwise make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale of the Lock-Up Securities, until twelve (12) months from the closing date of the Share Repurchase, subject to certain limited exceptions as set forth in the Share Purchase Agreement.

Perceptive Master Fund and its affiliates collectively own, in the aggregate, more than 10% of the Company's outstanding Ordinary Shares, and Perceptive Credit Holdings III, LP ("Perceptive Credit Holdings III"), an affiliate of Perceptive Master Fund, holds a $75 million note issued by the Companypursuant to the Amended and Restated Notes Purchase Agreement and Guaranty, dated December 19, 2022, between the Company, its wholly-owned subsidiaries MeiraGTx UK II Limited and MeiraGTx Ireland DAC, the noteholders and the other parties from time to time party thereto, and Perceptive Credit Holdings III, as administrative agent and noteholder (as amended, the "Notes Purchase Agreement"). Under the Share Purchase Agreement, Perceptive Credit Holdings consented to the Share Repurchase in accordance with the terms of the Notes Purchase Agreement. Additionally, Ellen Hukkelhoven, Ph.D., a member of the Company's Board of Directors, is Head of Biotechnology Investments of Perceptive Advisors.

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