Management Change/Compensation (Form 8-K)

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

OnKure Therapeutics, Inc. (the "Company") amended and restated its 2024 Equity Incentive Plan (the "A&R 2024 Plan"), effective as of June 3, 2026 upon approval by the stockholders of the Company at the Annual Meeting (as defined below).

The amendments to the Company's 2024 Equity Incentive Plan included (1) a one-time increase to the number of shares of common stock reserved for issuance by approximately 8% of the Company's outstanding shares (3,231,638 shares), (2) an amendment to the annual "evergreen" provision to remove the annual limit of 2,407,100 shares (which, prior to the 1:10 reverse stock split effected on October 4, 2024, had been 24,071,000 shares), while maintaining the annual increase at 5% of the Company's outstanding shares, and (3) limiting the number of shares that can be issued as incentive stock options under the plan.

The material terms of the A&R 2024 Plan are described in "Proposal No. 3: Approval of the OnKure Therapeutics, Inc. Amended and Restated 2024 Equity Incentive Plan" in the Company's definitive proxy statement on Schedule 14A filed with the United States Securities and Exchange Commission on April 21, 2026 (the "Proxy Statement"), which description is incorporated herein by reference.

The foregoing description of the A&R 2024 Plan is qualified in its entirety by reference to the text of the A&R 2024 Plan, which is filed as Exhibit 10.1 to this Current Report on Form 8-K and incorporated herein by reference.

Item 5.07 Submission of Matters to a Vote of Security Holders.

On June 3, 2026, the Company held its 2026 Annual Meeting of Stockholders (the "Annual Meeting"). At the Annual Meeting, the Company's stockholders voted on the three proposals set forth below. A more detailed description of each proposal is set forth in the Proxy Statement.

Proposal No. 1: Election of Directors

R. Michael Carruthers, Valerie M. Jansen, M.D., Ph.D. and Edward T. Mathers were each elected to serve as a Class II director of the Company's Board of Directors until the 2029 Annual Meeting of Stockholders and until their respective successors are elected and qualified, by the following votes:

Proposal No. 2: Ratification of the Selection of Independent Registered Public Accounting Firm

The stockholders ratified the selection of KPMG LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2026, by the following votes:

Proposal No. 3: Approval of the Amended and Restated 2024 Equity Incentive Plan

The stockholders approved the amendment and restatement of the Company's 2024 Equity Incentive Plan, by the following votes: