Exploring Preclinical In Vivo Services

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Mispro's In Vivo Services Make it Easier to Achieve Preclinical Success

Many think of contract vivaria as just a key card to research space-but Mispro offers far more. Our facilities combine fully equipped vivarium lab space with dedicated support services, a key factor in many preclinical success stories.

For some biotech companies, core in vivo pharmacology services such as veterinary care, animal husbandry, and regulatory compliance are enough. For others, particularly startups without in-house expertise, adding on Mispro's in vivo technical services can provide additional support needed to advance preclinical programs efficiently.

Learn more about how Mispro supports your research, and whether technical services will help your company achieve preclinical success.

Key Takeaways

• Mispro combines fully equipped vivarium space with animal husbandry, veterinary, and regulatory support to help biotech teams conduct in vivo rodent studies in-house.
• Add-on technical services provide hands-on support for biomethodology, surgical procedures, tissue collection, oncology research, and breeding colony management.
• Mispro's technical services enables biopharma companies to fill internal capability gaps for early-stage in vivo pharmacology studies such as efficacy, PK/PD, and ADME research.

Mispro's "Space + Services" Model

Mispro is a contract vivarium, which means biotechs get more than just vivarium lab space-they gain access to fully equipped facilities and expert husbandry, veterinary, and compliance support. Our all-inclusive vivarium delivers the tools and support biotechs need to conduct their own research and drive trusted preclinical outcomes.

Mispro In Vivo Services

Mispro has two types of service offerings: core services and technical services.

• Core Services (Included in Your Plan): Veterinary care, animal husbandry, regulatory compliance oversight (IACUC)
• Technical Services (Add-On Services): Compound/cell administration, blood/tissue collection, colony support and management, surgical prep.

Technical Services extend beyond the core services offered and are designed to help early-stage biopharma teams without in-house expertise, or those needing additional in vivo support, manage in vivo research and collect preclinical study data with confidence.

Core Services

With our core services, Mispro's certified animal care technicians and veterinary staff handle daily husbandry, veterinary oversight, and regulatory compliance, all included with your lab space.

Animal Husbandry

Mispro's certified animal care technicians manage daily food & water, cage cleaning, enrichment, and health monitoring, while veterinary staff oversee animal health issues and welfare.

Regulatory Oversight

Our in-house IACUC committee reviews all protocols to ensure compliance with applicable federal, state, and local regulations. Mispro maintains an OLAW/PHS assurance, alongside rigorous health monitoring, veterinary checks, documentation practices, and AAALAC-accreditation of its facilities and program.

Mispro Technical Services

Technical Services support early-stage biopharma companies that either lack internal resources and expertise. These services help companies manage procedures and timepoints within their in vivo research, enabling them to conduct preclinical studies in-house with confidence.

Basic Biomethodology

Mispro's biomethodology services provide expert dosing, monitoring, tissue collection, and colony care to ensure reliable preclinical data, study integrity, and the highest standards of animal welfare.

• Blood Collection - Skilled collection of blood samples from rodents using minimally invasive techniques, ensuring animal welfare and sample integrity.
• Animal Identification - Reliable methods for marking and tracking individual animals to maintain study accuracy and compliance.
• Dosing (IP, PO, SQ, IV) - Administration of compounds via intraperitoneal, oral, subcutaneous, or intravenous routes, following precise dosing protocols.
• Cancer Biology - Support for preclinical oncology studies, including tumor implantation, growth monitoring, and treatment evaluation.
• Clinical Observation & Assessments - Daily monitoring of animals for behavioral, physiological, and clinical signs to evaluate study endpoints.
• Necropsy - Performing terminal procedures to collect tissues and organs, with attention to study objectives and animal welfare.
• Colony Health Monitoring & Adverse Study Event Investigation - Ongoing evaluation of animal health and investigation of unexpected events to ensure study integrity.
• Terminal Tissue Collection - Harvesting tissues at study endpoints for downstream analysis such as histology, molecular assays, or PK/PD studies.
• Tissue Fixation - Proper preparation and preservation of tissue samples to maintain structural and molecular integrity for analysis.
• Sample Prep - Organization and labeling of sample collection tubes.

Pre-Operative Surgical Support

• Pre-Operative Preparation - Preparing animals, instruments, and surgical areas to ensure sterile, safe, and compliant procedures.
• Intra-Operative Monitoring - Continuous observation of vital signs during surgery to maintain animal safety and procedural success.
• Post-Operative Care & Monitoring - Comprehensive recovery support, including analgesia, observation, and intervention as needed to ensure welfare.

Breeding Colony Management

• Strain Lineage Management - Tracking and maintaining genetic lines to preserve colony integrity and experimental consistency.
• Pairing, Weaning, Collecting Samples for Genotyping - Managing breeding pairs, weaning pups, and collecting DNA samples to confirm genotypes.
• Phenotypic Characterization - Monitoring physical, behavioral, and biological traits to validate model suitability for specific studies.

Does My Biotech Need Technical Services?

In vivo Technical Services are designed to help early-stage biopharma startups lacking the internal capabilities to manage certain aspects of in vivo research, enabling them to conduct preclinical studies in-house with confidence.

You may benefit from in vivo technical services if your team:

• Lacks internal expertise to perform certain animal studies or procedures
• Wants to accelerate preclinical programs without building in-house capabilities
• Prefers to keep studies in-house while ensuring regulatory compliance and high-quality data

Mispro's Technical Services are designed to fill these gaps, giving early-stage biopharma companies the confidence and support needed to conduct in vivo research efficiently and successfully.

Studies We Support

In Mispro's contract vivarium facilities, we support a variety of in vivo (non-GLP) preclinical studies, including:

• Efficacy studies (how well a treatment works)
• Pharmacokinetics / Pharmacodynamics (PK/PD)
• ADME (absorption, distribution, metabolism, excretion)

Connect with a Mispro representative to discuss your animal research needs.

Mispro provides flexibility in space options and technical services, helping companies reach preclinical success on an expedited timeline.

Discuss your preclinical vivarium needs with a Mispro representative today.