Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * Versant Ventures VII GP, L.P. 2. Issuer Name and Ticker or Trading Symbol Lycia Therapeutics, Inc. [LYCA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) ONE SANSOME STREET, SUITE 1650 3. Date of Earliest Transaction (Month/Day/Year) 10/26/2026 (Street) SAN FRANCISCO, CA 94104 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 10/26/2026 C 5,631,425 A (1) 5,631,425 I See Footnote(2) Common Stock 10/26/2026 C 1,393,882 A (1) 1,393,882 I See Footnote(3)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Series A Preferred Stock

(1)

10/26/2026

C

25,390,410

(1)

(1)

Common Stock

5,631,425

(1)

0

I

See Footnote(2)

Series B Preferred Stock

(1)

10/26/2026

C

6,284,597

(1)

(1)

Common Stock

1,393,882

(1)

0

I

See Footnote(3)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Versant Ventures VII GP, L.P. ONE SANSOME STREET, SUITE 1650 SAN FRANCISCO, CA 94104		X
Versant Venture Capital VII, L.P. ONE SANSOME STREET, SUITE 1650 SAN FRANCISCO, CA 94104		X
Versant Ventures VII GP-GP, LLC ONE SANSOME STREET, SUITE 1650 SAN FRANCISCO, CA 94104		X
Versant Vantage II, L.P. ONE SANSOME STREET, SUITE 1650 SAN FRANCISCO, CA 94104		X
Versant Vantage II GP, L.P. ONE SANSOME STREET, SUITE 1650 SAN FRANCISCO, CA 94104		X
Versant Vantage II GP-GP, LLC ONE SANSOME STREET, SUITE 1650 SAN FRANCISCO, CA 94104		X

Signatures

Versant Venture Capital VII, L.P. By: Versant Ventures VII GP, L.P. Its: General Partner By: Versant Ventures VII GP-GP, LLC Its: General Partner By: /s/ Max Eisenberg Its: Chief Operating Officer		10/28/2026
**Signature of Reporting Person		Date
Versant Ventures VII GP, L.P., By: Versant Ventures VII GP-GP, LLC Its: General Partner By: /s/ Max Eisenberg Its: Chief Operating Officer		10/28/2026
**Signature of Reporting Person		Date
Versant Ventures VII GP-GP, LLC By: /s/ Max Eisenberg Its: Chief Operating Officer		10/28/2026
**Signature of Reporting Person		Date
Versant Vantage II, LP By: Versant Vantage II GP, L.P. Its: General Partner By: Versant Vantage II GP-GP, LLC Its: General Partner By: /s/ Max Eisenberg Its: Chief Operating Officer		10/28/2026
**Signature of Reporting Person		Date
Versant Vantage II GP, L.P., By: Versant Vantage II GP-GP, LLC Its: General Partner By: /s/ Max Eisenberg Its: Chief Operating Officer		10/28/2026
**Signature of Reporting Person		Date
Versant Vantage II GP-GP, LLC, By: /s/ Max Eisenberg Its: Chief Operating Officer		10/28/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock on a one-for-0.221793422 basis upon the closing of the Issuer's initial public offering on October 26, 2026, without payment of consideration. The Series A Preferred Stock and Series B Preferred Stock have no expiration date.
(2)	The shares are held directly by Versant Venture Capital VII, L.P. ("VVC VII"). Versant Ventures VII GP, L.P. ("VV VII GP") is the general partner of VVC VII, and Versant Ventures VII GP-GP, LLC ("VV VII GP-GP") is the general partner of VV VII GP. Each of VV VII GP-GP and VV VII GP disclaims beneficial ownership of the shares held by VVC VII, except to the extent of their respective pecuniary interests therein.
(3)	The shares are held directly by Versant Vantage II, L.P. ("VV II"). Versant Vantage II GP, L.P. ("VV II GP") is the general partner of VV II, and Versant Vantage II GP-GP, LLC ("VV II GP-GP") is the general partner of VV II GP. Each of VV II GP-GP and VV II GP disclaims beneficial ownership of the shares held by VV II, except to the extent of their respective pecuniary interests therein.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure. Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.