Material Event (Form 8-K)

Item 8.01 Other Events.

On April 28, 2025, Clene Inc. (the "Company") entered into an equity distribution agreement (the "Equity Distribution Agreement") with Canaccord Genuity LLC as placement agent (the "Placement Agent") to offer and sell shares of its common stock, par value $0.0001 per share ("Common Stock"), having an aggregate offering price of up to $25,000,000 from time to time through the Placement Agent. Prior to the date hereof, the Company sold shares of common stock having an aggregate sales price of approximately $3,706,213 under the Equity Distribution Agreement. On September 5, 2025, the Company filed a prospectus supplement under the Equity Distribution Agreement for an aggregate of $6,280,000 of additional shares of Common Stock. A copy of the legal opinion of Holland & Knight LLP, relating to the validity of the shares in connection with the Equity Distribution Agreement is filed as Exhibit 5.1 to this Current Report on Form 8-K and is incorporated herein by reference.