Management Change/Compensation (Form 8-K)

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On September 12, 2025, Sachin Pathigoda and Angel Liriano were appointed as directors of Shuttle Pharmaceuticals Holdings, Inc. (the "Company"). On September 15, 2025, Mr. Pathigoda was also appointed as the Chairman of the Nominating and Corporate Governance Committee and Mr. Liriano was appointed as the Chairman of the Compensation Committee. In addition, Mr. Pathigoda was appointed as a member of the Audit Committee and Mr. Liriano was appointed as a member of the Nominating and Corporate Governance Committee.

In addition, George Scorsis, a director of the Company, was appointed as Chairman of the Audit Committee.

There are no family relationships between Mr. Pathigoda or Mr. Liriano and any of the Company's directors or executive officers. Neither Mr. Pathigoda nor Mr. Liriano have any direct or indirect material interest in any transaction required to be disclosed pursuant to Item 404(a) of Regulation S-K. There were no arrangements or understandings by which Mr. Pathigoda and Mr. Liriano were appointed as directors of the Company..