Proxy Results (Form 8-K)

Item 5.07 Submission of Matters to a Vote of Security Holders.

The following is a summary of the matters voted on at the 2026 annual meeting of stockholders of Septerna, Inc. (the "Company"), held on June 26, 2026 (the "Annual Meeting").

Proposal No. 1

The Company's stockholders elected Shalini Sharp, M.B.A. and Jake Simson, Ph.D. to the Company's Board of Directors (the "Board") as Class II directors, each for a three-year term ending at the annual meeting of stockholders of the Company to be held in 2029 and each until his or her respective successor has been duly elected and qualified or until his or her earlier death, resignation or removal. The results of the stockholders' vote with respect to the election of the Class II directors were as follows:

Proposal No. 2

The Company's stockholders ratified the appointment of Ernst & Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2026. The results of the stockholders' vote with respect to such ratification were as follows:

No other matters were submitted to or voted on by the Company's stockholders at the Annual Meeting.