Insight Guru Inc.
10/22/2026 | Press release | Distributed by Public on 10/22/2026 03:39
Market Movers | Winners: NUAI, ENVX, ABTC | Losers: AVEX, TKNO, RCUS
The S&P 500 rose 0.6% on Wednesday, October 21, while the Nasdaq-100 jumped 1.1% and the Dow Jones Industrial Average gained 0.7%. The S&P 500 is now up 0.5% over five trading days and down 0.1% over the past month.
Within the Trefis coverage universe, 2,090 stocks rose and 1,976 fell. At the extremes, New Era Energy & Digital (NUAI) gained 17.7% and AEVEX (AVEX) fell 32.5%.
Wednesday's Market Winners
The 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the highest returns on Wednesday:
| # | Ticker | Company Name |
1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | NUAI | New Era Energy & Digital | 17.7% | 13.3% |
| 2 | ENVX | Enovix | 12.9% | -65.3% |
| 3 | ABTC | American Bitcoin | 12.5% | -66.1% |
| 4 | BNC | BNB Standard | 11.8% | -11.2% |
| 5 | ALMR | Alamar Biosciences | 11.7% | n/a |
| 6 | ELMT | Elmet | 11.5% | n/a |
| 7 | RCEL | AVITA Medical | 10.8% | 343.2% |
| 8 | ABSI | Absci | 10.7% | 187.7% |
| 9 | WGO | Winnebago Industries | 10.7% | -34.0% |
| 10 | NTSK | Netskope | 10.0% | 24.3% |
Wednesday's Market Losers
And the 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the lowest returns on Wednesday:
| # | Ticker | Company Name |
1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | AVEX | AEVEX | -32.5% | n/a |
| 2 | TKNO | Alpha Teknova | -20.8% | 53.9% |
| 3 | RCUS | Arcus Biosciences | -19.6% | -19.8% |
| 4 | RAPP | Rapport Therapeutics | -14.7% | -17.4% |
| 5 | MDXG | MiMedx | -11.6% | -44.8% |
| 6 | IART | Integra Lifesciences | -11.2% | -4.7% |
| 7 | CAPR | Capricor Therapeutics | -11.0% | n/a |
| 8 | LAD | Lithia Motors | -10.1% | -18.5% |
| 9 | FUN | Six Flags Entertainment | -10.1% | -53.9% |
| 10 | CTBI | Community Trust Bancorp | -9.3% | 24.1% |
Wednesday's Extremes Were Mostly Fresh Moves
None of the names on the one-day lists shows up on the same side of the one-month lists: Wednesday's extremes were new moves, not the continuation of a run.
Movers Over The Last Week
Widening the window to five trading days, these are the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name |
1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | BRZE | Braze | 61.7% | 33.2% |
| 2 | INDP | Indaptus Therapeutics | 43.0% | 8.6% |
| 3 | IRON | Disc Medicine | 36.3% | -4.3% |
| 4 | MYGN | Myriad Genetics | 34.2% | -9.4% |
| 5 | APPN | Appian | 26.7% | 37.6% |
| 6 | NAUT | Nautilus Biotechnology | 25.5% | 39.0% |
| 7 | TRAX | First Tracks Biotherapeutics | 25.3% | n/a |
| 8 | VRDN | Viridian Therapeutics | 25.2% | -26.1% |
| 9 | MAZE | Maze Therapeutics | 24.2% | -21.4% |
| 10 | ALMR | Alamar Biosciences | 24.0% | n/a |
Losers
| # | Ticker | Company Name |
1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | FMC | FMC | -37.8% | -63.0% |
| 2 | AVEX | AEVEX | -31.7% | n/a |
| 3 | TKNO | Alpha Teknova | -24.9% | 53.9% |
| 4 | FUN | Six Flags Entertainment | -20.9% | -53.9% |
| 5 | MDXG | MiMedx | -20.4% | -44.8% |
| 6 | GEMI | Gemini Space Station | -18.2% | -68.1% |
| 7 | TE | T1 Energy | -17.9% | -64.4% |
| 8 | TBN | Tamboran Resources | -17.8% | 6.6% |
| 9 | CBRS | Cerebras Systems | -16.6% | n/a |
| 10 | RCUS | Arcus Biosciences | -15.2% | -19.8% |
Movers Over The Last Month
And over the last 21 trading days, the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name |
1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | NAUT | Nautilus Biotechnology | 171.2% | 39.0% |
| 2 | BMBL | Bumble | 110.2% | 66.7% |
| 3 | BRZE | Braze | 79.0% | 33.2% |
| 4 | FIGS | FIGS | 54.3% | 75.9% |
| 5 | PCRX | Pacira BioSciences | 47.1% | 40.4% |
| 6 | PACB | Pacific Biosciences of California | 45.6% | 14.4% |
| 7 | RXO | RXO | 45.4% | 127.7% |
| 8 | CBRL | Cracker Barrel Old Country Store | 45.1% | 165.1% |
| 9 | HPK | HighPeak Energy | 44.5% | 137.6% |
| 10 | DXC | DXC Technology | 40.9% | 5.1% |
Losers
| # | Ticker | Company Name |
1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | EMAT | Evolution Metals & Technologies | -61.8% | n/a |
| 2 | EOSE | Eos Energy Enterprises | -58.6% | -85.3% |
| 3 | NUAI | New Era Energy & Digital | -52.4% | 13.3% |
| 4 | CIFR | Cipher Digital | -52.2% | -38.1% |
| 5 | FMC | FMC | -52.0% | -63.0% |
| 6 | PCT | PureCycle Technologies | -50.4% | -67.8% |
| 7 | QURE | uniQure | -49.9% | -5.2% |
| 8 | GEMI | Gemini Space Station | -46.8% | -68.1% |
| 9 | TE | T1 Energy | -45.4% | -64.4% |
Volatility Is The Cost Of Owning Stocks. Concentration Makes It A Bill
Every name on these lists made a move big enough to notice. A diversified holder reads that as noise; a concentrated holder feels it as real money. The difference is not the stock, it is the portfolio around it.
Building that portfolio is what the Trefis High Quality (HQ) Portfolio does: roughly 30 businesses with the cash generation and balance-sheet strength to absorb bad days, selected and rebalanced by rules. It has a track record of outpacing a benchmark that combines the S&P 500, the S&P MidCap 400, and the Russell 2000. Let the movers list remind you why diversification exists.
Insight Guru Inc. published this content on October 22, 2026, and is solely responsible for the information contained herein. Distributed via Public Technologies (PUBT), unedited and unaltered, on October 22, 2026 at 09:39 UTC. If you believe the information included in the content is inaccurate or outdated and requires editing or removal, please contact us at [email protected]