Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Longitude Capital Partners II, LLC 2. Issuer Name and Ticker or Trading Symbol RAPID MICRO BIOSYSTEMS, INC. [RPID] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O LONGITUDE CAPITAL MANAGEMENT, 2740 SAND HILL ROAD, 2ND FLOOR 3. Date of Earliest Transaction (Month/Day/Year) 01/23/2026 (Street) MENLO PARK, CA 94025 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Class A Common Stock 01/23/2026 X(1) 629,032 A $0.05 4,036,984 I Held by Longitude Venture Partners II, L.P.(2) Class A Common Stock 01/23/2026 S(1) 7,739 D $4.064 4,029,245 I Held by Longitude Venture Partners II, L.P.(2) Class A Common Stock 01/30/2026 S 46,000 D $4.5435 104,000 I Held by Longitude Prime Fund, L.P.(3) Class A Common Stock 02/02/2026 S 27,500 D $4.246 76,500 I Held by Longitude Prime Fund, L.P.(3) Class A Common Stock 02/03/2026 S 27,500 D $4.2415 49,000 I Held by Longitude Prime Fund, L.P.(3)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Class A Common Stock

$0.05

01/23/2026

X

500,000

(4)

07/24/2027

Class A Common Stock

500,000

$ 0

0

I

Held by Longitude Venture Partners II, L.P.(2)

Class A Common Stock

$0.05

01/23/2026

X

129,032

(4)

01/17/2028

Class A Common Stock

129,032

$ 0

0

I

Held by Longitude Venture Partners II, L.P.(2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Longitude Capital Partners II, LLC C/O LONGITUDE CAPITAL MANAGEMENT 2740 SAND HILL ROAD, 2ND FLOOR MENLO PARK, CA 94025		X
Longitude Venture Partners II, L.P. 2740 SAND HILL ROAD, SECOND FLOOR MENLO PARK, CA 94025		X
Longitude Prime Partners, LLC 2740 SAND HILL ROAD, SECOND FLOOR MENLO PARK, CA 94025		X
ENRIGHT PATRICK G 2740 SAND HILL ROAD, SECOND FLOOR MENLO PARK, CA 94025		X
Tammenoms Bakker Juliet 2740 SAND HILL ROAD, SECOND FLOOR MENLO PARK, CA 94025		X

Signatures

/s/ Longitude Capital Partners II, LLC, By: /s/ Cristiana Blauth Oliveira, Authorized Signatory		02/03/2026
**Signature of Reporting Person		Date
/s/ Longitude Venture Partners II, L.P., By: /s/ Cristiana Blauth Oliveira, Authorized Signatory		02/03/2026
**Signature of Reporting Person		Date
/s/ Longitude Prime Partners, LLC, By: /s/ Cristiana Blauth Oliveira, Authorized Signatory		02/03/2026
**Signature of Reporting Person		Date
/s/ Longitude Prime Fund, L.P., By: /s/ Cristiana Blauth Oliveira, Authorized Signatory		02/03/2026
**Signature of Reporting Person		Date
/s/ Cristiana Blauth Oliveira, as attorney-in-fact for Patrick G. Enright		02/03/2026
**Signature of Reporting Person		Date
/s/ Cristiana Blauth Oliveira, as attorney-in-fact for Juliet Tammenoms Bakker		02/03/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Longitude Venture Partners II, L.P. ("LVPII") exercised warrants to purchase an aggregate of 629,032 shares of the Issuer's Class A common stock for $0.05 per share and paid the exercise price on a cashless basis, resulting in the Issuer withholding 7,739 shares of the Issuer's shares of Class A common stock subject to the warrant to pay the exercise price.
(2)	The securities are held directly by LVPII. Longitude Capital Partners II, LLC, ("LCPII"), the general partner of LVPII, may be deemed to have voting and dispositive power with respect to the shares held by LVPII. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCPII and may be deemed to share voting and dispositive power over the shares held by LVPII. Each of LCPII, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.
(3)	The securities are held directly by Longitude Prime Fund, L.P. ("LPF"). Longitude Prime Partners, LLC ("LPP"), the general partner of LPF, may be deemed to have voting and dispositive power with respect to the shares held by LPF. Mr. Enright and Ms. Tammenoms Bakker are the managing members of LPP and may be deemed to have voting and dispositive power over the shares held by LPF. LPP and each of Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.
(4)	The warrant is immediately exercisable.

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