FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * MCGUIRE TERRANCE 2. Issuer Name and Ticker or Trading Symbol Seer, Inc. [SEER] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O SEER, INC., 3800 BRIDGE PARKWAY 3. Date of Earliest Transaction (Month/Day/Year) 12/09/2025 (Street) REDWOOD CITY, CA 94065 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Class A Common Stock 12/09/2025 C 4,088 A (1) 215,070 I See footnote(2) Class A Common Stock 112,066 D Class A Common Stock 78,947 I See footnote(3)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Class B Common Stock

(1)

12/09/2025

C

4,088

(1)

(1)

Class A Common Stock

4,088

$ 0

0

I

See footnote(2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
MCGUIRE TERRANCE C/O SEER, INC. 3800 BRIDGE PARKWAY REDWOOD CITY, CA 94065	X

Signatures

/s/ David Horn, by power of attorney		12/11/2025
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Pursuant to the Issuer's amended and restated certificate of incorporation, as amended, each share of the Issuer's Class B Common Stock automatically converted into one share of Class A Common Stock at the close of business on the first day following the fifth anniversary of the closing of the Issuer's initial public offering.
(2)	The reported shares are held of record by Strong Bridge, LLC for which the Reporting Person serves as an operating manager.
(3)	The reported shares are held of record by Polaris Founders Capital Fund I, L.P. ("PFCF I"). Polaris Founders Capital Management Co. I, L.L.C. ("PFCM"), is the general partner of PFCF I. The Reporting Person and Jonathan A. Flint ("Flint") are the managing members of PFCM. Each of the Reporting Person and Flint in their respective capacities with respect to PFCM may be deemed to have shared voting and dispositive power with respect to the shares held by PFCF I. Each of PFCM, Flint, and the Reporting Person disclaims beneficial ownership of securities held by PFCF I, and this report shall not be deemed an admission that the Reporting Person, Flint, or PFCM is the beneficial owner of these securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

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