Material Agreement (Form 8-K)

On August 20, 2025, scPharmaceuticals Inc. (the "Company") entered into an amendment (the "Amendment") to that certain Supply Agreement, dated August 15, 2020, by and between the Company and West Pharmaceutical Services, Inc. ("West"), pursuant to which the Company agreed to purchase the SmartDose® drug delivery system developed by West (the "Agreement").

The Amendment provides for, among other things: (i) that the term of the Agreement will continue in effect until December 31, 2027 and does not automatically extend or automatically renew and (ii) upon election of termination of the Agreement by either party, that the Company will be responsible for payment to West for any costs incurred and purchase orders accepted through the date of termination of the Agreement.

The foregoing description of the Amendment is a summary, and is qualified in its entirety by reference to such document, which is filed herewith as Exhibit 10.1 to this Current Report on Form 8-K,and is incorporated herein by reference.