Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * GOLDSMITH MARK A 2. Issuer Name and Ticker or Trading Symbol Revolution Medicines, Inc. [RVMD] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) See Remarks (Last) (First) (Middle) C/O REVOLUTION MEDICINES, INC., 700 SAGINAW DRIVE 3. Date of Earliest Transaction (Month/Day/Year) 11/07/2025 (Street) REDWOOD CITY, CA 94063 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/07/2025 M(1) 26,479 A $1.12 374,342(2)(3) D Common Stock 11/07/2025 M(1) 3,521 A $4.09 377,863(2)(3) D Common Stock 11/07/2025 S(1) 30,000 D $60.3102(4) 347,863(2)(3) D Common Stock 11/12/2025 G(5) 50,000 D $ 0 297,863(2)(3) D Common Stock 11/12/2025 G(6) 50,000 D $ 0 247,863(2)(3) D Common Stock 11/12/2025 G 50,000 A $ 0 70,424 I Trust(7) Common Stock 11/12/2025 G 50,000 A $ 0 54,498(8) I Trust(9) Common Stock 15,926(8) I Trust(10) Common Stock 570,050(2) I Trust(11)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Option (Right to Buy)

$1.12

11/07/2025

M(1)

26,479

03/29/2022

04/19/2028

Common Stock

26,479

$ 0

0

D

Stock Option (Right to Buy)

$4.09

11/07/2025

M(1)

3,521

03/13/2023

03/12/2029

Common Stock

3,521

$ 0

177,708

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
GOLDSMITH MARK A C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY, CA 94063	X		See Remarks

Signatures

/s/ Jack Anders, as attorney-in fact for Mark A. Goldsmith		11/12/2025
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Transaction made pursuant to a 10b5-1 trading plan adopted by Mark A. Goldsmith on December 19, 2024.
(2)	Reflects the transfer of 104,446 shares previously held directly by the Reporting Person into a family trust.
(3)	Includes 193,475 restricted stock units.
(4)	This transaction was executed in multiple trades at prices ranging from $60.00 to $60.88. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(5)	Represents a transfer to the Jonathan Goldsmith Revocable Trust.
(6)	Represents a transfer to the Rebecca Goldsmith Revocable Trust.
(7)	Held by Jonathan Goldsmith Revocable Trust.
(8)	Reflects the transfer of 4,498 shares.
(9)	Held by Rebecca Goldsmith Revocable Trust.
(10)	Held by Rebecca Eve Goldsmith Trust under the Goldsmith Children's 2011 Irrevocable Education Trust, dated December 15, 2011.
(11)	Held by Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust.
Remarks: President and Chief Executive Officer

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