On September 18, 2025, Nuwellis, Inc. (the "Company") announced that the United States Patent and Trademark Office has issued U.S. Patent No. 12,415,021 on September 16, 2025, based on Application No. 18/298,860. The patent relates to the use of one or more hemolysis sensors with extracorporeal blood filtration systems-such as ultrafiltration therapy and continuous renal replacement therapy (CRRT)-to help detect and localize red blood cell destruction occurring within or around the circuit. The intellectual property supports the Company's pediatric device, Vivian, in development and future platform innovation.