Insight Guru Inc.
10/20/2026 | Press release | Distributed by Public on 10/19/2026 22:39
Market Movers | Winners: IRON, NAUT, ANNX | Losers: HPP, ALM, GEMI
The S&P 500 advanced 0.4% on Monday, October 19, while the Nasdaq-100 rallied 1.2% and the Dow Jones Industrial Average slipped 0.1%. Over the past week the S&P 500 is down 1.5%, and over the past month it is up 0.5%.
Decliners outnumbered gainers 2,448 to 1,651 within the Trefis coverage universe. Disc Medicine (IRON) gained 38.9% to lead the day, while Hudson Pacific Properties (HPP) fell 12.4%, the weakest showing.
Monday's Market Winners
The 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the highest returns on Monday:
| # | Ticker | Company Name |
1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | IRON | Disc Medicine | 38.9% | -0.6% |
| 2 | NAUT | Nautilus Biotechnology | 27.7% | 34.9% |
| 3 | ANNX | Annexon | 17.6% | -20.1% |
| 4 | CLF | Cleveland-Cliffs | 16.3% | 6.2% |
| 5 | MANE | Veradermics | 12.4% | n/a |
| 6 | AGIO | Agios Pharmaceuticals | 11.4% | 28.2% |
| 7 | ARQT | Arcutis Biotherapeutics | 10.7% | 9.8% |
| 8 | PRME | Prime Medicine | 10.4% | 10.4% |
| 9 | AXTI | AXT | 10.3% | 247.3% |
| 10 | GLUE | Monte Rosa Therapeutics | 9.4% | -32.0% |
Monday's Market Losers
And the 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the lowest returns on Monday:
| # | Ticker | Company Name |
1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | HPP | Hudson Pacific Properties | -12.4% | -16.7% |
| 2 | ALM | Almonty Industries | -10.2% | 0.2% |
| 3 | GEMI | Gemini Space Station | -9.9% | -67.6% |
| 4 | FNMA | Federal National Mortgage Association Fannie Mae | -9.0% | -68.1% |
| 5 | FMCC | Federal Home Loan Mortgage | -8.5% | -69.0% |
| 6 | OCUL | Ocular Therapeutix | -8.4% | -48.2% |
| 7 | IBRX | ImmunityBio | -8.3% | 325.3% |
| 8 | DJT | Trump Media & Technology | -8.0% | -51.4% |
| 9 | WERN | Werner Enterprises | -7.9% | 2.3% |
| 10 | FOXF | Fox Factory | -7.8% | -13.6% |
Which Of Monday's Movers Were Already On A Run?
Nautilus Biotechnology (NAUT) appears on both the one-day and one-month winners lists. It rose 27.7% on Monday and is up 172.3% over the past month; excluding Monday, it had already gained 113.3% over the other sessions.
Gemini Space Station (GEMI) added to a longer slide: after Monday's 9.9% decline, the stock is down 44.7% over the past month, and it was already down 38.6% before Monday.
Movers Over The Last Week
Widening the window to five trading days, these are the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name |
1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | BMBL | Bumble | 56.8% | 66.9% |
| 2 | IRON | Disc Medicine | 30.5% | -0.6% |
| 3 | LQDA | Liquidia | 23.3% | -1.0% |
| 4 | BH | Biglari | 23.0% | 35.3% |
| 5 | ARQT | Arcutis Biotherapeutics | 21.6% | 9.8% |
| 6 | NAUT | Nautilus Biotechnology | 21.2% | 34.9% |
| 7 | BH-A | Biglari | 20.7% | 25.4% |
| 8 | CBRL | Cracker Barrel Old Country Store | 17.9% | 178.3% |
| 9 | GRNT | Granite Ridge Resources | 17.9% | 28.9% |
| 10 | HPK | HighPeak Energy | 17.3% | 140.3% |
Losers
| # | Ticker | Company Name |
1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | FMC | FMC | -35.6% | -60.6% |
| 2 | CIFR | Cipher Digital | -31.2% | -39.4% |
| 3 | FUN | Six Flags Entertainment | -30.3% | -45.8% |
| 4 | PENG | Penguin Solutions | -28.6% | 189.1% |
| 5 | BLZE | Backblaze | -26.6% | 99.4% |
| 6 | VICR | Vicor | -26.5% | 74.0% |
| 7 | HPP | Hudson Pacific Properties | -25.9% | -16.7% |
| 8 | RXT | Rackspace Technology | -25.5% | n/a |
| 9 | FLEX | FLEX | -25.3% | 44.9% |
| 10 | EOSE | Eos Energy Enterprises | -24.3% | -84.2% |
Movers Over The Last Month
And over the last 21 trading days, the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name |
1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | NAUT | Nautilus Biotechnology | 172.3% | 34.9% |
| 2 | BMBL | Bumble | 113.6% | 66.9% |
| 3 | CBRL | Cracker Barrel Old Country Store | 53.7% | 178.3% |
| 4 | GRAL | GRAIL | 51.6% | n/a |
| 5 | FIGS | FIGS | 48.9% | 71.2% |
| 6 | MRNA | Moderna | 47.3% | n/a |
| 7 | PCRX | Pacira BioSciences | 47.2% | 40.4% |
| 8 | TTAN | ServiceTitan | 42.2% | -26.5% |
| 9 | PTC | PTC | 42.1% | 10.8% |
| 10 | SG | Sweetgreen | 41.0% | 50.6% |
Losers
| # | Ticker | Company Name |
1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | EMAT | Evolution Metals & Technologies | -61.7% | n/a |
| 2 | EOSE | Eos Energy Enterprises | -54.3% | -84.2% |
| 3 | CIFR | Cipher Digital | -51.3% | -39.4% |
| 4 | QURE | uniQure | -49.5% | -7.2% |
| 5 | LQDA | Liquidia | -49.0% | -1.0% |
| 6 | PCT | PureCycle Technologies | -49.0% | -66.0% |
| 7 | FMC | FMC | -46.4% | -60.6% |
| 8 | NKTR | Nektar Therapeutics | -45.4% | -13.3% |
| 9 | BLSM | BlossomHill Therapeutics | -45.0% | n/a |
| 10 | GEMI | Gemini Space Station | -44.7% | -67.6% |
The Tape Rewards Attention. It Punishes Reaction
Big daily moves pull hard at both greed and fear, and acting on either, day after day, is how most portfolios end up trailing the index they were trying to beat.
The Trefis High Quality (HQ) Portfolio is built for the opposite reflex: about 30 quality businesses screened for the fundamentals that survive volatile stretches, held with rules instead of reactions. It has a track record of outpacing a benchmark that combines the S&P 500, the S&P MidCap 400, and the Russell 2000. Read the movers daily; trade them rarely.
Insight Guru Inc. published this content on October 20, 2026, and is solely responsible for the information contained herein. Distributed via Public Technologies (PUBT), unedited and unaltered, on October 20, 2026 at 04:39 UTC. If you believe the information included in the content is inaccurate or outdated and requires editing or removal, please contact us at [email protected]