Initial Registration Statement for Employee Benefit Plan (Form S-8)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

____________

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

____________

Aethlon Medical, Inc.

(Exact name of registrant as specified in its charter)

____________

Nevada		13-3632859
(State or other jurisdiction of incorporation)		(I.R.S. Employer Identification No.)

11555 Sorrento Valley Road, Suite 203

San Diego, California 92121

(Address of principal executive offices) (Zip Code)

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Aethlon Medical, Inc. 2020 Equity Incentive Plan

(Full title of the plan)

____________

James B. Frakes

Chief Executive Officer and Chief Financial Officer

Aethlon Medical, Inc.

11555 Sorrento Valley Road, Suite 203

San Diego, California 92121

(619) 941-0360

(Name, address, and telephone number, including area code, of agent for service)

____________

Copies to:

Dennis J. Doucette, Esq.

Procopio, Cory, Hargreaves & Savitch LLP

12544 High Bluff Drive, Suite 400

San Diego, CA 92130

(858) 720-6300

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated Filer	☐	Accelerated Filer	☐
Non-accelerated Filer	☒	Smaller reporting company	☒
		Emerging Growth Company	☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act ☐

REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E

Pursuant to General Instruction E of Form S-8, Aethlon Medical, Inc. (the "Company") is filing this Registration Statement on Form S-8 (this "Registration Statement") to register an additional 100,000 shares of the Company's common stock, par value $0.001 per share (the "Common Stock"), issuable pursuant to the Company's 2020 Equity Incentive Plan, as amended (the "2020 Plan"). The additional shares were authorized pursuant to an amendment to the 2020 Plan approved by the Company's stockholders on October 1, 2026.

The additional 100,000 shares of Common Stock are in addition to the shares of Common Stock previously registered for issuance under the 2020 Plan pursuant to the Company's Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the "Commission") on September 15, 2020 (File No. 333-248820), September 19, 2022 (File No. 333-267504), November 15, 2024 (File No. 333-283690), and June 10, 2026 (File No. 333-296684). Pursuant to General Instruction E of Form S-8, the contents of those registration statements are hereby incorporated by reference into this Registration Statement, except to the extent modified or superseded by the information contained herein or in any subsequently filed document incorporated by reference herein.

Effective June 6, 2025, the Company effected a one-for-eight reverse stock split of its Common Stock, with trading on a split-adjusted basis commencing June 9, 2025. Effective October 16, 2025, the Company effected a one-for-ten reverse stock split of its Common Stock, with trading on a split-adjusted basis commencing October 20, 2025. Effective July 31, 2026, the Company effected a one-for-five reverse stock split of its Common Stock, with trading on a split-adjusted basis commencing August 4, 2026 (collectively, the "Reverse Stock Splits"). The number of shares of Common Stock issuable under the 2020 Plan was adjusted, as applicable, to reflect the Reverse Stock Splits.

The approval of the amendment to the 2020 Plan by the Company's stockholders at its 2026 Annual Meeting of Stockholders is described in the Company's Current Report on Form 8-K filed with the Commission on October 1, 2026, as amended by the Company's Current Report on Form 8-K/A filed with the Commission on October 5, 2026, each of which is incorporated herein by reference.

PART II

INFORMATION REQUIRED IN REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference.

The following documents, which have been filed by the Company with the Commission pursuant to the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended (the "Exchange Act"), are incorporated herein by reference:

	·	The Company's Annual Report on Form 10-K for the fiscal year ended March 31, 2026, filed with the Commission on June 10, 2026;
	·	The Company's Quarterly Report on Form 10-Q for the quarter ended June 30, 2026, filed with the Commission on August 13, 2026;
	·	The Company's Current Reports on Form 8-K filed with the Commission on June 10, 2026, July 8, 2026, July 31, 2026, August 31, 2026, September 15, 2026, September 17, 2026, October 1, 2026, and October 9, 2026, and the Company's Current Report on Form 8-K/A filed with the Commission on October 5, 2026, in each case excluding any information furnished rather than filed with the Commission; and
	·	The description of the Company's Common Stock contained in the Company's Registration Statement on Form 8-A, filed with the Commission pursuant to Section 12(b) of the Exchange Act on July 8, 2015, including any amendments or reports filed for the purpose of updating such description, including Exhibit 4.16 to the Company's Annual Report on Form 10-K for the fiscal year ended March 31, 2020, filed with the Commission on June 25, 2020.

All reports and other documents filed by the Company pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items, after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of filing such reports and documents.

Any statement contained in a document incorporated by, or deemed incorporated by reference herein, shall be deemed to be modified or superseded for purposes of this registration statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.

Item 8. Exhibits.

(d) Exhibits

				Incorporation by Reference
Exhibit Number		Exhibit Description		Form		Filing Date		Exhibit		Filed Herewith
4.1		Articles of Incorporation, as amended.		8-K		September 19, 2022		3.1
4.2		Certificate of Amendment to Articles of Incorporation.		8-K		February 23, 2026		3.1
4.2		Certificate of Amendment to Articles of Incorporation.		8-K		October 9, 2026		3.1
4.3		Amended and Restated Bylaws of the Company.		8-K		September 12, 2019		3.1
5.1		Opinion of Procopio, Cory, Hargreaves & Savitch LLP.								X
23.1		Consent of Haskell & White LLP, independent registered public accounting firm.								X
23.2		Consent of Procopio, Cory, Hargreaves & Savitch LLP (incorporated by reference to Exhibit 5.1 to this Registration Statement on Form S-8).								X
24.1		Power of Attorney (included on the signature page hereto)								X
99.1		Aethlon Medical, Inc. 2020 Equity Incentive Plan, as amended to date, Form of Restricted Stock Grant, Form of Option Grant and Agreement.		8-K		October 1, 2026		10.1
107		Filing Fee Table								X

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on November 12, 2026.

	Aethlon Medical, Inc.
	By:	/s/ James B. Frakes
	James B. Frakes
	Chief Executive Officer and Chief Financial Officer

POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints James B. Frakes as the undersigned's true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution for such person and in such person's name, place and stead, in any and all capacities, to file and sign any and all amendments to this Registration Statement, including any and all post-effective amendments, and to file such amendments thereto, with exhibits thereto and other documents in connection therewith, with the Commission, granting unto said attorney-in-fact and agent, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his or her substitutes, may lawfully do or cause to be done by virtue hereof.

***

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed below by the following persons in the capacities and on the dates indicated.

Signature		Title		Date
/s/ James B. Frakes		Chief Executive Officer, Chief Financial Officer and Director (Principal Executive, Financial and Accounting Officer)		November 12, 2026
James B. Frakes
/s/ Edward G. Broenniman		Chairman of the Board, Director		November 12, 2026
Edward G. Broenniman
/s/ Chetan Shah		Director		November 12, 2026
Chetan Shah, MD
/s/ Angela Rossetti		Director		November 12, 2026
Angela Rossetti
/s/ Nicolas Gikakis		Director		November 12, 2026

Nicolas Gikakis