Results of the joint call for projects aimed at accelerating the use of artificial intelligence and/or high-performance computing within the Luxembourg innovation ecosystem

On 5 February, the nine projects retained for co-funding in the context of the joint call for projects 'High-Performance Computing and Artificial Intelligence' were announced by the Ministry of the Economy and the Luxembourg National Research Fund (FNR), following the final phase of the selection process.

This joint call for projects was launched together with Luxinnovation in spring 2.025 via the research-industry-collaboration-platform.

The objective of the call for projects was to accelerate the use of AI and/or HPC within Luxembourg's innovation ecosystem with a particular focus on AI for industry and scientific innovation, HPC for advanced simulations and data processing or cross-domain projects combining AI and HPC.

The joint call aimed to stimulate collaborative research & development projects in the form of public-private partnerships (PPPs), offering financial support to companies and research organizations, in order to foster the development of new applications, services, and technological capabilities that exploit the potential of AI and HPC for the benefit of and society.

The selection process took place in several steps. In the final phase, 17 consortia have submitted full project proposals, evaluated by an independent expert panel. Following this assessment, 9 projects were selected to receive funding.

Presentation of the 9 selected projects

The project 'Artificial Intelligence for neurodegenerative diseases Care (AID-Care)' suggested by the company NTT Luxembourg PSF S.A. in collaboration with the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg leverages AI to transform unstructured health records into interoperable dementia datasets, enabling personalized care and advancing research across Luxembourg and Japan.

Total budget: 1,806 million euros

The project "Neuro-Symbolic Reasoning for Embedded System Architectures Design (NEURESA)", proposed by COGNIFYER and the University of Luxembourg, aims to develop an intelligent agent-based computer-aided design (CAD) software that integrates AI-driven modelling, combined with natural language interfaces, neuro-symbolic constraint solving, and GPU-accelerated computation, thus enabling users to design complex electronic systems for cars in a much more efficient, reliable, and accessible way.

Total budget: 1,135 million euros

The company WEO and the Luxembourg Institute of Science and Technology (LIST) collaborate on the EASE project, which aims to tackle the growing climate-resilience challenges faced by cities. By combining High-Performance Computing with advanced Super-Resolution (SR) and Explainable AI (XAI) techniques, the project enhances the quality of freely available satellite data, enabling more accurate and interpretable environmental monitoring despite the limitations of costly high-resolution imagery.

Total budget: 1,110 million euros

The objective of the collaborative project of the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and Exobiosphere is the development of an integrated platform combining simulated microgravity experiments, i.e. as if they were taking place in space, with artificial intelligence and high-performance computing for physiologically relevant modelling of Parkinson's disease.

Total budget: 1,434 million euros

The project 'Gene Perturbation Prediction Systems (GenePPS)' is suggested by Helical and the University of Luxembourg to develop hybrid AI models combining graph neural networks and foundation models to predict gene perturbation effects, reduce experimental costs, and accelerate precision medicine and drug discovery.

Total budget: 931.000 euros

Together with the Interdisciplinary Centre for Security, Reliability and Trust (SnT) of the University of Luxembourg, the company Hydrosat is implementing a project to make satellite-to-ground data transmission more efficient and cost-effective. They are developing an end-to-end, AI-powered cloud-detection and compression system for thermal infrared Earth-observation images, using high-performance computing to allow satellites to send data to the ground more easily while using less energy and bandwidth.

Total budget: 1,423 million euros

This joint project 'AI4Kids: Norm-First & HPC-Verified Interactive Agents for Child-facing Applications' of the company LuxAI and the University of Luxembourg targets the development of a child-centred AI framework that integrates norm-first generative AI, goal-directed planning, and explainable decision-making to ensure safe, pedagogically aligned, and compliant interactions for children in sensitive contexts such as education and healthcare.

Total budget: 1,666 million euros

Orange Communications Luxembourg, together with the Luxembourg Institute of Science and Technology (LIST), is carrying out the collaborative project "RAISE: Radio Access Intelligence for Saving Energy." The project aims to design and test AI-powered methods that reduce the energy consumption of mobile Radio Access Networks while maintaining a high quality of service for users. To achieve this, the partners use data-driven modelling and digital-twin simulations to evaluate and optimize network performance under real-world conditions.

Total budget: 1,309 million euros

Paul Wurth S.A., in collaboration with the University of Luxembourg, is working on a project that focuses on a key sustainability challenge: reducing carbon emissions in ironmaking. The project is called "HISEED": High-Fidelity Multiphase CFD Simulations for Hydrogen-Based Iron Ore Reduction in Circulating Fluidized Beds. The project aims to build a simulation framework that can accurately model the process of hydrogen-based direct reduction of iron ore in circulating fluidized bed reactors. To achieve this, it uses detailed fluid-flow simulations supported by high-performance computing.

Total budget: 773.000 euros

The Minister of the Economy, SMEs, Energy and Tourism, Lex Delles, commented: "The results of this joint call for projects demonstrate the remarkable dynamism of our innovation ecosystem. By supporting projects that use artificial intelligence and high-performance computing, we are strengthening the competitiveness of businesses and research centres, while helping to accelerate Luxembourg's digital sovereignty. The selected projects perfectly illustrate our desire to encourage public-private partnerships, stimulating innovation in the field of AI and HPC for the benefit of society."

Dr Isabelle Mossong, Secretary General of the Luxembourg National Research Fund (FNR) commented: "For the FNR, this joint call demonstrates the value of bringing together scientific excellence and industrial ambition. The funded projects highlight how research and industry can jointly push the boundaries of what AI and HPC can achieve when expertise is shared and challenges are tackled collaboratively. These results show that Luxembourg's research community is ready to translate advanced knowledge into meaningful innovation, strengthening our capacity to address complex societal and economic needs. We are pleased to support partnerships that not only advance science but also reinforce Luxembourg's position as a place where impactful, mission-driven research thrives."

Mario Grotz, CEO of Luxinnovation, adds: "The quality of the selected projects demonstrates, on the one hand, the dynamism of our entire ecosystem and, on the other, the strong complementarity between the various stakeholders involved. Supported by a robust digital infrastructure, in which the MeluXina supercomputer is one of the cornerstones, and backed by highly specialised and recognised expertise in the field of research, companies and start-ups benefit from powerful support to develop and deliver innovative products and services. By facilitating such connections between public and private actors, we activate a key lever of innovation."

Next steps

The planning of the joint calls for projects for 2.026 and 2.027 can be accessed online. In this context, and in alignment with the strategic initiative of the government "Accelerating Digital Sovereignty 2.030", a joint call for projects in the fields of Data, Artificial Intelligence (AI) and/or Quantum will be open for submission from March, 1st.

Communiqué par le Ministère de l'Economie / Luxinnovation / Fonds national de la recherche (FNR)

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Press release by the Ministry of the Economy / Luxinnovation / Luxembourg National Research Fund (FNR)