Next-Generation Imaging and Radiation Therapy Launch at City of Hope Chicago

Chicago - City of Hope® Cancer Center Chicago is expanding its radiation oncology capabilities with the addition of two advanced technologies designed to improve precision, efficiency and patient outcomes. City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States, is among the first in Chicago to offer patients adaptive radiation therapy.

City of Hope Chicago's Downtown Clinic is now home to the Ethos™ therapy system, which combines artificial intelligence-driven adaptive treatment with real-time imaging. Unlike traditional radiation therapy, which relies on scans taken before treatment begins, the Ethos system can re-image and adapt treatment plans prior to each session, allowing for more precise, personalized care. This capability allows the radiation oncology team to adjust the treatment plan immediately, accounting for day-to-day anatomical changes in the body such as organ movement and tumor response.

"City of Hope Chicago is leveraging AI-driven technology like our new Ethos linear accelerator to personalize cancer care so that clinicians are no longer locked into a single care plan," said radiation oncologist Dr. Kevin King. "We can re-image the patient and adapt treatment daily, allowing for precision radiation oncology."

In addition, beginning summer 2026, City of Hope Downtown Chicago will offer Siemens Biograph mCT system, an advanced PET/CT platform that expands both diagnostic imaging and radiation therapy planning capabilities.

PET/CT maps the cancer before treatment begins, while the Ethos system adapts radiation therapy in real time each day. Together, they enable more personalized treatment with greater precision, minimizing the margin of error where healthy tissue also receives radiation therapy out of an abundance of caution. The end result is fewer side effects and improved quality of life for patients.

"Our approach is powerful because anatomy is dynamic. Organs move and tumors can shrink over the course of therapy. We can now adjust in real time and deliver the most precise treatment plan possible for each patient, every single day," King said.

Key benefits of adaptive radiation therapy:

• Prevents damage of healthy tissue with daily adaptive radiation dosing
• Real-time planning via CT-based onboard imaging
• Most effective for "shifty" cancers like prostate, pancreatic, and head and neck cancers that can move or change from day to day

Advanced PET/CT Imaging Enhances Diagnosis and Treatment Planning

City of Hope Cancer Center Chicago now offers the Siemens Biograph mCT system, an advanced PET/CT platform that expands both diagnostic imaging and radiation therapy planning capabilities.

Benefits of the Biograph mCT system:

• High-resolution imaging capable of detecting and defining small lesions
• Quantitative reproducibility for radiation therapy planning and follow-up
• Streamlined PET/CT workflow that improves the patient experience with fewer side effects and less radiation to healthy organs nearby.
• Wide-bore design to improve comfort for patients with claustrophobia or higher BMI

Precision Oncology Through Integrated Technology

City of Hope is among only a few systems regionally using the combined technologies in a tri-modality capacity, allowing it to function as both a high-resolution PET/CT scanner and a radiation therapy CT simulator. This integrated approach helps improve efficiency and consistency throughout the care process.

Together, the Ethos adaptive therapy system and the Biograph mCT PET/CT platform create a highly integrated environment for precision radiation oncology.

By combining advanced imaging with adaptive treatment capabilities, City of Hope clinicians can deliver:

• More precise initial treatment planning
• Accurate daily treatment adaptation
• Improved differentiation between tumor and normal tissue
• Reduced radiation exposure to healthy organs
• Lower risk of treatment-related toxicity

To learn more about City of Hope's innovative cancer research and clinical care, please visit CityofHope.org.

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About City of Hope
City of Hope's mission is to make hope a reality for all touched by cancer and diabetes. Founded in 1913, City of Hope has grown into one of the largest and most advanced cancer research and treatment organizations in the United States, and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center that is ranked among the nation's top cancer centers by U.S. News & World Report at its core, City of Hope's uniquely integrated model spans cancer care, research and development, academics and training, and a broad philanthropy program that powers its work. City of Hope's growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and cancer treatment centers and outpatient facilities in the Atlanta, Chicago and Phoenix areas. City of Hope's affiliated group of organizations includes Translational Genomics Research Institute and AccessHopeTM. For more information about City of Hope, follow us on Facebook, X, YouTube, Instagram and LinkedIn.