Prospectus Certification by Investment Company (Form 497J)

September 28, 2026

VIA ELECTRONIC FILING

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Attention: Division of Investment Management

RE: BlackRock Large Cap Focus Growth Fund, Inc.

Post-Effective Amendment No. 45 to the Registration Statement on Form N-1A

(Securities Act File No. 333-89775, Investment Company Act File No.

811-09651)

Ladies and Gentlemen:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended (the "1933 Act"), BlackRock Large Cap Focus Growth Fund, Inc. (the "Fund"), hereby certifies that:

(1) the form of Prospectuses and Statement of Additional Information that would have been filed pursuant to Rule 497(c) under the 1933 Act would not have differed from that contained in Post-Effective Amendment No. 45 to the Registration Statement on Form N-1A of the the Fund; and

(2) the text of Post-Effective Amendment No. 45 to the Registration Statement on Form N-1A of the Fund was filed electronically with the Securities and Exchange Commission on September 25, 2026.