Material Event (Form 8-K)

Item 8.01. Other Events.

Dismissal of Indictment of Dr. Hoau-Yan Wang

On October 23, 2025, the United States District Court for the District of Maryland granted the United States' unopposed motion to dismiss with prejudice the criminal indictment against Hoau-Yan Wang, PhD. Dr. Wang is a former scientific collaborator and advisor to Cassava Sciences, Inc. ("Cassava" or the "Company") who conducted foundational research relating to the Company's investigational drug, simufilam. Among other things, the dismissed charges had accused Dr. Wang of causing Cassava to submit grant applications to the U.S. National Institutes of Health that allegedly contained false and fraudulent representations about his research and of manipulating or otherwise fabricating research results, including Western Blot images that he prepared. This order permanently terminates the case against Dr. Wang, and future charges related to the dismissed indictment cannot be refiled against Dr. Wang.

Cassava Sciences recognizes and supports the critical importance of integrity in all forms of scientific research. The Company continues to move forward with its current program evaluating simufilam as a potential treatment for Tuberous Sclerosis Complex (TSC)-related epilepsy based on research conducted at numerous institutions.