Initial Registration Statement for Employee Benefit Plan (Form S-8)

As filed with the Securities and Exchange Commission on August 11, 2026.

Registration No.

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D. C. 20549

Form S-8

REGISTRATION STATEMENT UNDER THE
SECURITIES ACT OF 1933

DIAMEDICA THERAPEUTICS INC.

(Exact Name of Registrant as Specified in its Charter)

British Columbia, Canada		Not Applicable
(State or other jurisdiction of incorporation or organization)		(I.R.S. Employer Identification No.)
301 Carlson Parkway, Suite 210 Minneapolis, Minnesota		55305
(Address of Principal Executive Offices)		(Zip Code)

DiaMedica Therapeutics Inc.
Amended and Restated 2019 Omnibus Incentive Plan

(Full Title of the Plan)

Rick Pauls

President and Chief Executive Officer

DiaMedica Therapeutics Inc.

301 Carlson Parkway, Suite 210

Minneapolis, Minnesota 55305

(Name and Address of Agent for Service)

Telephone number, including area code, of agent for service: (763) 496-5454

Copies to:

Jonathan R. Zimmerman Joshua L. Colburn Faegre Drinker Biddle & Reath LLP 2200 Wells Fargo Center 90 South Seventh Street Minneapolis, Minnesota 55402-3901

Keith Inman Pushor Mitchell LLP 301 - 1665 Ellis Street Kelowna, British Columbia Canada V1Y 2B3

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large Accelerated Filer ☐	Accelerated Filer ☐
Non accelerated Filer ☒	Smaller Reporting Company ☒
	Emerging Growth Company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

DIAMEDICA THERAPEUTICS INC.

EXPLANATORY NOTE

This Registration Statement on Form S-8 (the "Registration Statement") of DiaMedica Therapeutics Inc. (the "Registrant" or the "Company") is being filed pursuant to General Instruction E to Form S-8 under the United States Securities Act of 1933, as amended (the "Securities Act"), to register an additional 3,500,000 voting common shares, no par value per share, of the Company (the "Common Shares") available for issuance under the DiaMedica Therapeutics Inc. Amended and Restated 2019 Omnibus Incentive Plan (the "2019 Plan"). The share increase was approved by the Company's Board of Directors on March 16, 2026 and by the Company's shareholders at the Company's 2026 Annual General Meeting of Shareholders held on May 20, 2026. On May 23, 2024, the Company filed with the United States Securities and Exchange Commission (the "SEC") a Registration Statement on Form S-8 (File No. 333-279710) (the "2024 Registration Statement") to register an additional 3,000,000 Common Shares available for issuance under the 2019 Plan. On August 11, 2022, the Company filed with the SEC a Registration Statement on Form S-8 (File No. 333-266789) (the "2022 Registration Statement") to register an additional 2,000,000 Common Shares available for issuance under the2019 Plan. On May 23, 2019, the Company filed with the SEC a Registration Statement on Form S-8 (File No. 333-231717) (the "2019 Registration Statement" and, together with the 2022 Registration Statement and 2024 Registration Statement, the "Prior Registration Statements") to register the initial 2,000,000 Common Shares available for issuance under the DiaMedica Therapeutics Inc. 2019 Omnibus Incentive Plan. The contents of the Prior Registration Statements, with the exception of Items 3, 6 and 8 of Part II of such Prior Registration Statements, are hereby incorporated by reference.

PART II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference.

The Company hereby incorporates by reference into this Registration Statement the following documents which have been previously filed (not furnished) with the SEC:

(a)

The Company's Annual Report on Form 10-K for the year ended December 31, 2025;

(b)

The Company's Quarterly Reports on Form 10-Q for the quarters ended March 31, 2026 and June 30, 2026;

(c)

The Company's Current Reports on Form 8-K (other than portions thereof furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits accompanying such reports that are related to such items) filed with the SEC on March 31, 2026, May 6, 2026 and May 21, 2026;

(d)

All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the annual report referred to in (a) above (other than information deemed to have been "furnished" rather than "filed" in accordance with the Commission's rules); and

(e)

The description of the Company's Common Shares which is contained in Exhibit 4.1 to the Company's Annual Report on Form 10-K for the year ended December 31, 2025 and any amendment or report filed for the purpose of updating such description.

In addition, all other documents filed (not furnished) by the Company pursuant to Section 13(a), Section 13(c), Section 14 or Section 15(d) of the Securities Exchange Act of 1934, as amended, on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered hereby have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated in this Registration Statement by reference and to be a part of this Registration Statement from the date of filing of such documents; provided, however, that documents or information deemed to have been furnished to and not filed with the SEC in accordance with the rules of the SEC shall not be deemed incorporated by reference into this Registration Statement.

Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

Item 6. Indemnification of Directors and Officers.

British Columbia Law

Under Section 160 of the British Columbia Business Corporations Act (BCBCA), the Company may indemnify an eligible party including, but not limited to, a current or former director or officer of the Company; a current or former director or officer of another corporation: (i) at a time when the corporation is or was an affiliate of the Company, or (ii) at the Company's request; or, an individual who, at the Company's request, is or was, or holds or held, a position equivalent to that of a director or officer of a partnership, trust, joint venture or other unincorporated entity against all judgments, penalties or fines awarded or imposed in, or an amount paid in settlement of a proceeding in which an eligible party or any of the heirs and personal or other legal representatives of the eligible party, by reason of such party having been a director or officer of, or holding or having held a position equivalent to that of a director or officer of, the Company or an associated corporation, to which such party is or may be liable. Indemnification will be prohibited under Section 163 of the BCBCA if (i) giving the indemnity or paying the expenses is or was prohibited by the Company's Articles, (ii) if in relation to the subject matter of the eligible proceeding, the eligible party did not act honestly and in good faith with a view to the best interests of the Company or the associated corporation, as the case may be, or (iii) in the case of an eligible proceeding other than a civil proceeding, if the eligible party did not have reasonable grounds for believing that the eligible party's conduct in respect of which the proceeding was brought was lawful. The BCBCA also provides, under Section 162, that the Company may also advance moneys to an eligible party for expenses actually and reasonably incurred in connection with such a proceeding; however, prior to making any such advance, the Company must receive from the eligible party a written undertaking that if it is ultimately determined that the payment of expenses is prohibited by either conditions (i), (ii) or (iii) above, the eligible party will repay the amounts advanced.

DiaMedica's Articles

The Company's Articles provide that the Company shall indemnify, and pay expenses either as they are incurred in advance of the final disposition of an eligible proceeding or after the final disposition of an eligible proceeding of, a current or former director, and his or her heirs and legal personal representatives, or any person designated by the Company, in accordance with, and to the fullest extent and in all circumstances permitted by, the BCBCA.

The foregoing description of the Company's Articles is only a summary and is qualified in its entirety by the full text of the foregoing.

Indemnification Agreements

The Company has entered into and, in the future, will enter into indemnification agreements with its officers and directors in respect of any legal claims or actions initiated against them in their capacity as officers and directors of the Company or its subsidiaries in accordance with applicable law. These agreements include bearing the reasonable cost of legal representation in any legal or regulatory action in which they may become involved in their capacity as the Company's officers and directors. Pursuant to such indemnities, the Company will bear the cost of the representation of certain officers and directors.

Insurance Policies

The Company maintains insurance for certain liabilities incurred by the Company's directors and officers in their capacity with the Company or its subsidiaries.

SEC's Position on Indemnification

Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling the Company pursuant to the foregoing provisions, the Company has been informed that in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act, and is, therefore, unenforceable.

Item 8. Exhibits.

Exhibit No.		Description of Exhibit
4.1		Notice of Articles of DiaMedica Therapeutics Inc. dated May 20, 2025 (incorporated by reference to DiaMedica's Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2025)
4.2		Amended and Restated Articles of DiaMedica Therapeutics Inc. Effective May 17, 2023 (incorporated by reference to Exhibit 3.1 to DiaMedica's Current Report on Form 8-K filed with the Securities and Exchange Commission on May 18, 2023)
5		Opinion of Pushor Mitchell LLP (filed herewith)
23.1		Consent of Baker Tilly US, LLP (filed herewith)
23.2		Consent of Pushor Mitchell LLP (included in Exhibit 5.1)
24.1		Powers of Attorney (included on signature page)
99		DiaMedica Therapeutics Inc. Amended and Restated 2019 Omnibus Incentive Plan (incorporated by reference to Exhibit 10.1 to DiaMedica's Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2026)
107		Filing Fee Table (filed herewith)

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Minneapolis, State of Minnesota, on August 11, 2026.

	DIAMEDICA THERAPEUTICS INC.
	By:	/s/ Rick Pauls
		Rick Pauls President and Chief Executive Officer

POWERS OF ATTORNEY

Each person whose signature appears below hereby constitutes and appoints Rick Pauls and Scott Kellen, and each of them acting individually, as his or her true and lawful attorneys-in-fact and agents, with full power of each to act alone, with full powers of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign the Registration Statement filed herewith and any and all amendments to said Registration Statement (including post-effective amendments), and file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, with full power of each to act alone, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following persons on behalf of the Registrant and in the capacities and on the dates indicated:

Signature		Title		Date
/s/ Rick Pauls		President, Chief Executive Officer and Director		August 11, 2026
Rick Pauls		(principal executive officer)
/s/ Scott Kellen		Chief Financial Officer and Secretary		August 11, 2026
Scott Kellen		(principal financial and accounting officer)
/s/ Michael Giuffre, M.D.		Director		August 11, 2026
Michael Giuffre, M.D.
/s/ Richard Kuntz, M.D.		Director		August 11, 2026
Richard Kuntz, M.D.
/s/ Tanya N. Lewis		Director		August 11, 2026
Tanya N. Lewis
/s/ Daniel O'Connor		Director		August 11, 2026
Daniel O'Connor
/s/ James Parsons		Chairman of the Board, Director		August 11, 2026
James Parsons
/s/ Charles Semba, M.D.		Director		August 11, 2026
Charles Semba, M.D.