Material Event (Form 8-K)

On December 19, 2025, NextCure, Inc. (the "Company") entered into an at the market offering agreement (the "ATM Agreement") with H.C. Wainwright & Co., LLC (the "Agent"), pursuant to which the Company may sell, from time to time, up to an aggregate sales price of $14,500,000 of its common stock, $0.001 par value per share (the "Common Stock"), through the Agent. Actual sales will depend on a variety of factors to be determined by the Company from time to time, including, among other things, market conditions, the trading price of the Common Stock, capital needs and determinations by the Company of the appropriate sources of funding for the Company.

The Common Stock sold in the offering will be issued pursuant to a prospectus supplement filed with the Securities and Exchange Commission (the "SEC") on December 19, 2025, and the accompanying base prospectus dated August 4, 2023, forming part of the Company's registration statement on Form S-3 (Registration No. 333-273723).

Sales of the Common Stock, if any, made pursuant to the ATM Agreement may be sold in negotiated transactions or transactions that are deemed to be an "at the market offering", as defined in Rule 415(a)(4) of the Securities Act of 1933, as amended (the "Securities Act"), including sales made directly on or through the Nasdaq Global Select Market, on or through any other existing trading market for the Common Stock or by any other method permitted by law, at market prices prevailing at the time of sale, at prices related to prevailing market prices or at negotiated prices, or as otherwise agreed between the Company and the Agent. The Agent will be entitled to compensation equal to 3.0% of the gross proceeds from the sale of all shares of Common Stock sold under the ATM Agreement.

The Company intends to use any net proceeds from the offering, if any, for general corporate purposes and working capital, including for preclinical studies and clinical trials and the advancement of our product candidates.

The Company made certain customary representations, warranties and covenants concerning the Company and the registration statement in the ATM Agreement and also agreed to indemnify the Agent against certain liabilities, including liabilities under the Securities Act. The foregoing description of the ATM Agreement does not purport to be complete and is subject to, and is qualified in its entirety by reference to, the ATM Agreement, which is attached hereto as Exhibit 1.1 and is incorporated herein by reference.

On December 19, 2025, Sidley Austin LLP delivered its legality opinion with respect to the Common Stock to be issued from time to time pursuant to the ATM Agreement. A copy of the legality opinion is attached hereto as Exhibit 5.1.

This Current Report on Form 8-K shall not constitute an offer to sell or a solicitation of an offer to buy any securities, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction.