Registration Statement - Additional Securities (Form S-3MEF)

As filed with the Securities and Exchange Commission on April 22, 2026.

Registration No. 333-   

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-3

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

Altimmune, Inc.

(Exact name of registrant as specified in its charter)

Delaware		20-2726770
(State or other jurisdiction of incorporation or organization)		(I.R.S. Employer Identification Number)

910 Clopper Road, Suite 201S

Gaithersburg, Maryland 20878

(240) 654-1450

(Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)

Jerome Durso

President and Chief Executive Officer

Altimmune, Inc. 910 Clopper Road, Suite 201S

Gaithersburg, Maryland 20878

(240) 654-1450 (Name, address, including zip code, and telephone number, including area code, of agent for service)

With copies to:

Joseph C. Theis, Jr.

Justin S. Anslow

Goodwin Procter LLP

100 Northern Avenue

Boston, Massachusetts 02210

Telephone: (617) 570-1000

Approximate date of commencement of proposed sale to the public: From time to time after this registration statement becomes effective.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ¨

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, as amended, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box:x

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.x 333-291329

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.¨

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box.¨

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box.¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer		¨		Accelerated filer	¨
Non-accelerated filer		x		Smaller reporting company	x
				Emerging growth company	¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.¨

The Registration Statement shall become effective upon filing in accordance with Rule 462(b) under the Securities Act of 1933, as amended.

EXPLANATORY NOTE AND INCORPORATION OF

CERTAIN INFORMATION BY REFERENCE

Pursuant to Rule 462(b) under the Securities Act of 1933, as amended, Altimmune, Inc. (the "Registrant") is filing this Registration Statement on Form S-3 (this "Registration Statement") with the Securities and Exchange Commission (the "Commission"). This Registration Statement relates to the public offering of securities contemplated by the Registration Statement on Form S-3 (File No. 333-291329) (the "Prior Registration Statement"), which the Registrant initially filed with the Commission on November 6, 2025, and which the Commission declared effective on December 5, 2025.

The Registrant is filing this Registration Statement for the sole purpose of increasing the aggregate amount of securities offered by the Registrant by a proposed aggregate offering price of $65,000,000. The additional securities that are being registered for issuance and sale are in an amount and at a price that together represent no more than 20% of the maximum aggregate offering price of unsold securities under the Prior Registration Statement. The information set forth in the Prior Registration Statement and all exhibits to the Prior Registration Statement are hereby incorporated by reference into this Registration Statement.

The required opinion and consents are listed on the Exhibit Index below and filed herewith or incorporated by reference herein.

PART II

INFORMATION NOT REQUIRED IN PROSPECTUS

Item 16.

Exhibits

All exhibits filed with or incorporated by reference in the Registration Statement on Form S-3 (File No. 333-291329) are incorporated by reference into, and shall be deemed a part of, this Registration Statement, and the following additional exhibits are filed herewith, as part of this Registration Statement:

Exhibit No.		Description
5.1		Opinion of Goodwin Procter LLP.
23.1		Consent of Ernst & Young LLP Independent Registered Public Accounting Firm.
23.2		Consent of Goodwin Procter LLP (see Exhibit 5.1).
24.1		Power of Attorney (incorporated by reference to Exhibit 24.1 to the Prior Registration Statement).
107		Filing Fee Table.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this Registration Statement on Form S-3 to be signed on its behalf by the undersigned, thereunto duly authorized, in Gaithersburg, Maryland, on the 22^nd day of April, 2026.

Altimmune, Inc.
By:	/s/ Jerome Durso
	Jerome Durso
	President and Chief Executive Officer

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed below by the following persons in the capacities and on the dates indicated.

Signatures		Title		Date
/s/ Jerome Durso		President, Chief Executive Officer and Chairman of the Board
Jerome Durso		(Principal Executive Officer)		April 22, 2026
/s/ Gregory Weaver		Chief Financial Officer
Gregory Weaver		(Principal Financial Officer and Principal Accounting Officer)		April 22, 2026
*
John Gill		Director		April 22, 2026
*
Philip Hodges		Director		April 22, 2026
*
Diane Jorkasky, M.D.		Director		April 22, 2026
*
Teri Lawver		Director		April 22, 2026
*
Wayne Pisano		Director		April 22, 2026
*
Mitchel Sayare, Ph.D.		Director		April 22, 2026
*
Klaus O. Schafer, MD.		Director		April 22, 2026
*
Catherine Sohn, Pharm D		Director		April 22, 2026

*By:	/s/ Gregory Weaver
	Gregory Weaver
	Attorney-in-fact