Material Event (Form 8-K)

On December 23, 2025, Aethlon Medical, Inc., a Nevada corporation (the "Company"), filed a prospectus supplement (the "Prospectus Supplement") with the Securities and Exchange Commission (the "Commission") relating to the offer and sale of shares of the Company's common stock, par value $0.001 per share ("Common Stock"), from time to time pursuant to that certain At Market Offering Agreement, dated March 24, 2022, as amended on December 19, 2025 (the "ATM Agreement"), by and between the Company and H.C. Wainwright & Co., LLC ("Wainwright"). The Prospectus Supplement was filed together with the base prospectus dated January 2, 2026 (the "Base Prospectus" and together with the Prospectus Supplement, the "Prospectus"), under the Company's Registration Statement on Form S-3 (File No. 333-292405), which became effective on January 2, 2026 (the "Registration Statement").

On June 4, 2026, the Company filed Amendment No. 1 to the Prospectus Supplement (the "Amendment" and together with the Base Prospectus and the Prospectus Supplement, the "Prospectus"), amending and supplementing the Prospectus Supplement to update the amount of shares eligible for sale pursuant to General Instruction I.B.6 of Form S-3. Following the filing of the Amendment, the Company may offer and sell shares of Common Stock having an aggregate offering price of up to $542,716 pursuant to the ATM Agreement (the "Placement Shares"). This amount is in addition to the shares of Common Stock having an aggregate sales price of $1,849,457 that were previously sold pursuant to the Prospectus Supplement prior to the filing of the Amendment. As of June 1, 2026, the Company had 2,344,886 shares of Common Stock outstanding, of which 2,337,629 shares were held by non-affiliates for purposes of calculating the Company's public float under General Instruction I.B.6 of Form S-3. All other terms of the offering and the ATM Agreement remain unchanged and are described in the Prospectus Supplement and the ATM Agreement.

The legal opinion of Procopio, Cory, Hargreaves & Savitch, LLP relating to the Placement Shares is filed as Exhibit 5.1 to this Current Report on Form 8-K.

The offering of the Placement Shares has been registered pursuant to the Registration Statement, and any offering of the Placement Shares will be made only by means of the Prospectus. This Current Report on Form 8-K shall not constitute an offer to sell or the solicitation of an offer to buy any of the Placement Shares described herein, nor shall there be any sale of such securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.