Initial Statement of Beneficial Ownership (Form 3)

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Leperlier Cyrille 2. Date of Event Requiring Statement (Month/Day/Year) 03/18/2026 3. Issuer Name and Ticker or Trading Symbol NuCana plc [NCNA] (Last) (First) (Middle) C/O NUCANA PLC, 3 LOCHSIDE WAY 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) 5. If Amendment, Date Original Filed (Month/Day/Year) (Street) EDINBURGH EH12 9DT 6. Individual or Joint/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Options	(1)	(1)	Ordinary Shares	32,823,199	(1)	D
Options	(2)	(2)	Ordinary Shares	32,823,199	(2)	D
Options	(3)	(3)	Ordinary Shares	39,466,743	(3)	D
Options	(4)	(4)	Ordinary Shares	39,466,743	(4)	D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Leperlier Cyrille C/O NUCANA PLC 3 LOCHSIDE WAY EDINBURGH EH12 9DT	X

Signatures

/s/ Ian Webster, Attorney-in-Fact for Cyrille Leperlier		03/18/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The ordinary shares, nominal value 0.0004 Pounds Sterling per share (the "Ordinary Shares"), of NuCana plc (the "Company") underlying this option have an exercise price of 0.004 Pounds Sterling, completed vesting on June 20, 2025 and expire June 20, 2035.
(2)	The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest in full on June 20, 2026, subject to the Reporting Person's continued service with the Company through the applicable vesting date.
(3)	The Ordinary Shares underlying this option have an exercise price of 0.0005 Pounds Sterling, completed vesting on January 14, 2026 and expire January 14, 2036.
(4)	The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest in full on January 14, 2027, subject to the Reporting Person's continued service with the Company through the applicable vesting date.
Remarks: Exhibit 24.1 - Power of Attorney

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