Material Event (Form 8-K)

In connection with its underwritten offering announced today, Cibus, Inc. ("Cibus" or the "Company") is providing the following disclosures, which update and supplement the Company's existing business disclosures, as follows:

Company Overview

We are a leading agricultural biotechnology company that uses proprietary gene editing technologies to develop plant traits, which are specific genetic characteristics in the DNA of a plant's seed. These plant traits, or characteristics, influence how a resulting plant functions and/or interacts with its environment.

Our Primary Business

Our primary business is the development of plant traits for some of the world's major agricultural food crops that help address specific productivity, profitability, sustainability, or yield challenges in farming. These plant traits can be licensed to global seed companies where the licensee company will include these traits in their seed products and for which we will receive an annual royalty for seed sold, usually structured as a per-acreplanted royalty. This is not a new business model as many companies have developed traits that have been added to seed products and have garnered significant royalties for their developers over many years. Importantly, farmers are well acquainted with the value of these seeds with traits. Our initial focus is on productivity traits, which can be associated with improving crop yields in the face of challenges such as weeds, pests, and diseases, can address environmental challenges with an overall reduction in the use of chemicals like fungicides, insecticides, or fertilizers, or can make crops more adaptable to environmental factors such as heat and drought in the face of climate change. In the near term, our priority pipeline program centers on Rice herbicide tolerance traits.

Our business operates within the global seed market, where management estimates that aggregate trait value across genetically modified organism ("GMO") and non-GMOseeds globally represents approximately $12.0 billion.

Priority Programs

In June 2025, building on efficiencies from restructuring initiatives introduced in late 2024 to date, we announced further streamlining of our operational focus to preserve capital resources and concentrate our working capital expenditures on the commercial advancement of the Company's weed management traits for Rice. On July 21, 2025, our Board of Directors approved a reduction in workforce of approximately 34 full-time employees as a pivotal step in implementing our streamlined business focus, which reduction in workforce was completed as of December 31, 2025.

We believe our Rice herbicide tolerance traits represent potential annual accessible royalties of over $200 million upon full commercialization across our initial target markets of Latin America and the United States. There are over 400 million acres of rice grown globally across five key regions (estimated: United States, 3 million acres; Latin America, 6.5 million acres; India, 120 million acres; Asia (excluding China), 60 million acres; and China, 75 million acres). Our longer term strategy targets approximately 200 million of these acres across the United Sates, Latin America, India and Asia (excluding China).

Alongside our fully company-funded Rice program, we also continue to advance our sustainable ingredients work, which includes a yeast fermentation biofragrance products program and our crop based lauric oils program, the development of which are currently partially funded and/or supported by a consumer-packaged goods partner. In 2025, we began receiving initial nominal payments associated with the ongoing commercialization efforts for our biofragrance products program. Based on management estimates regarding our expansion to additional fragrances and assumptions around peak future sales, we estimate that future annual revenue potential for the biofragrance products program could reach as high as $20-40 millionover a long-term horizon.

Over the course of 2025, we implemented streamlining cost reduction actions, including rationalizing human capital resources and certain non-corefacilities, which we anticipate have the potential to reduce our annual net cash usage to approximately $30.0 million or less during the course of 2026. We anticipate that such efforts will contribute toward improved cash flow and financial stability. We are in the process of completing the consolidation of our core operations in San Diego, CA while prioritizing resources on advancing our Rice programs and completing ongoing or delaying future planned non-Riceactivities that are not partner-funded, such as field testing.

Opportunity Programs

While prioritizing the Company's weed management traits for Rice and partially partner-funded sustainable ingredients (biofragrance and lauric oils) programs, we also retain the rights to the remainder of our productivity trait portfolio and will opportunistically pursue partner-funded projects in such traits until such time as our capital resources are sufficient to efficiently support a more robust development effort. Development activities to date, such as in-processfield and greenhouse trials, will continue through completion.

Crop Access & Royalty Targets and Opportunities

The table below summarizes our management's current beliefs and estimates regarding crop access and royalty targets and opportunities for our priority and opportunity programs. These statements represent forward-looking statements and their achievement is subject to numerous risks and uncertainties. See "Cautionary Note Regarding Forward-Looking Statements."

The table below summarizes the current development status of the traits for our priority and opportunity programs.

Our Technologies

Our core technology is our propriety gene editing platform called the Rapid Trait Development System^™ orRTDS^®. It is the underlying technology for our Trait Machine^™ process, providing a standardized end-to-end,semi-automated, high-throughput gene editing system that directly edits seed companies' elite germplasm. It is a time bound, reproducible, and predictable science-based breeding process. TheRTDScan accelerate a plant breeding system, leading to a more industrialized approach to traits like herbicide tolerance (HT), which provide farmers with novel weed management solutions to increase their productivity. Over 500 patents or patents pending coverRTDSand many of our gene edited traits. We consider the Trait Machine process an important technological milestone that represents a breakthrough in the achievement of a standardized, high-throughput gene editing system that provides the speed, precision, and scale to develop a new class of high value productivity traits that is the promise of gene editing.

Gene-edited traits are importantly distinguishable from traits developed with GMO. While GMO technologies enabled major improvements in farming productivity, they have faced regulatory and adoption headwinds because of their use of foreign DNA, or transgenic material. For example, in the European Union, GMO traits were essentially banned, and imports were heavily regulated. However, in December 2025, trilogue negotiations on NGTs in the European Union positively concluded, marking a crucial advancement toward formal approval of new NGT legislation in the EU. The agreement on proposed final legislative text, which represents the final step in advancing the EU's NGT legislation for adoption, reflects a framework for the

development and growing of gene edited plants that are equivalent to those produced through conventional breeding, excluding herbicide tolerance traits that will be classified as Category 2 plants subject to the EU's GMO legislation.

Signaling a favorable global trend, numerous regulatory agencies in the United States, Canada, Latin America, Africa, and Southeast Asia, have confirmed that ourRTDS-developed trait products are non-transgenicand are not subject to heightened GMO regulation in these markets. Below is a map graphically showing Cibus management's assessment of the global regulatory framework. As used in the map, "Regulatory Policy in Place" means that gene edited crops are regulated more similarly to conventional crops and not GMOs, "Regulatory Policy Developments" means that ongoing research regulations are in development, but no current timeline or regulatory guidance has been established, and "Policy Discussions Underway" means the regulatory status of gene editing of crops has not been favorably determined. Hash marks indicate countries with regulatory policy advanced or in place, with ongoing positive developments.